A canção

"A Room At The Heartbreak Hotel" tem a letra creditada a Bono e a produção levando o nome de Jimmy Lovine. Os backing vocais da música, crescentes na parte final, são de Maxine Waters e Julia Waters. As duas são integrantes do grupo The Waters - composto por quatro membros da família Waters (entre os artistas com os quais já colaboraram com backing vocals, estão Neil Diamond e Michael Jackson).

A canção foi oficialmente lançada em Dezembro de 1988, como B-side da versão remixada de "Angel of Harlem", pela Island Records. Alcançou o 9° lugar no topo das paradas do Reino Unido, o 14° lugar nos EUA, e o 15° no Canadá.

Esse B-side é uma referência direta a Elvis Presley, que havia lançado uma música chamada "Heartbreak Hotel".

A letra possivelmente trata a respeito de uma personagem feminina que acaba por confundir sexo com amor.

From where I stand
I can see through you
From where you're sitting, pretty one
I know it got to you

I see the stars in your eyes
You want the truth, but you need the lies
Like Judy Garland, like Valentino
You give your life for rock n' roll
A-ha

Stand
We're on a landslide of love
You got everything you want
But what you need
You give away

For primitive love
And a ride on the mystery train
A primitive love
A room at the heart
The heartbreak hotel
A room at the heartbreak
Heartbreak hotel
A room at the heartbreak
Heartbreak hotel

You say it's love, it's not the money
You let them suck your life out like honey
Turning tricks, you're on the street
Selling your kisses so bittersweet

I wanna know
Did you bet again ?
I gotta know
Oh the price
Is to hard to pay

A primitive love
A and a ride on the mystery train
A primitive love
A room at the heart
The heartbreak hotel

A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel

A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel
A room at the heartbreak, the heartbreak,
The heartbreak hotel, hotel

Clique aqui para ver a tradução da letra!